Apoptosis in the striatum of rats following intraperitoneal injection of 3-nitropropionic acid

Shuzo Sato, Glenn T. Gobbel, Jari Honkaniemi, Yibing Li, Takeo Kondo, Kensuke Murakami, Minako Sato, Jean Christophe Copin, Pak H. Chan

研究成果: Article

39 引用 (Scopus)

抜粋

The present study investigated the mechanism of cellular degeneration within the striatum following administration of the mitochondrial toxin, 3-nitropropionic (3-NP) acid. Internucleosomal fragmentation typical of apoptosis was present in the DNA of cells from the striatum of 3-NP-treated rats. DNA fragmentation was also evident in this region by terminal deoxynucleotidyl transferase-mediated dUTP-biotin nick end labeling. The data suggest that striatal cells die by apoptosis following administration of 3-NP.

元の言語English
ページ(範囲)343-347
ページ数5
ジャーナルBrain research
745
発行部数1-2
DOI
出版物ステータスPublished - 1997 1 16

ASJC Scopus subject areas

  • Neuroscience(all)
  • Molecular Biology
  • Clinical Neurology
  • Developmental Biology

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  • これを引用

    Sato, S., Gobbel, G. T., Honkaniemi, J., Li, Y., Kondo, T., Murakami, K., Sato, M., Copin, J. C., & Chan, P. H. (1997). Apoptosis in the striatum of rats following intraperitoneal injection of 3-nitropropionic acid. Brain research, 745(1-2), 343-347. https://doi.org/10.1016/S0006-8993(96)01231-0