Apoptosis in the striatum of rats following intraperitoneal injection of 3-nitropropionic acid

Shuzo Sato, Glenn T. Gobbel, Jari Honkaniemi, Yibing Li, Takeo Kondo, Kensuke Murakami, Minako Sato, Jean Christophe Copin, Pak H. Chan

研究成果: Article査読

41 被引用数 (Scopus)

抄録

The present study investigated the mechanism of cellular degeneration within the striatum following administration of the mitochondrial toxin, 3-nitropropionic (3-NP) acid. Internucleosomal fragmentation typical of apoptosis was present in the DNA of cells from the striatum of 3-NP-treated rats. DNA fragmentation was also evident in this region by terminal deoxynucleotidyl transferase-mediated dUTP-biotin nick end labeling. The data suggest that striatal cells die by apoptosis following administration of 3-NP.

本文言語English
ページ(範囲)343-347
ページ数5
ジャーナルBrain research
745
1-2
DOI
出版ステータスPublished - 1997 1月 16
外部発表はい

ASJC Scopus subject areas

  • 神経科学(全般)
  • 分子生物学
  • 臨床神経学
  • 発生生物学

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