Apatite-forming ability of carboxyl group-containing polymer gels in a simulated body fluid

M. Kawashita, M. Nakao, M. Minoda, H. M. Kim, T. Beppu, T. Miyamoto, T. Kokubo, T. Nakamura

研究成果: Article査読

191 被引用数 (Scopus)

抄録

Carboxymethylated chitin, gellan gum, and curdlan gels were soaked in a simulated body fluid (SBF) having ion concentrations nearly equal to those of human blood plasma. Some of the gels had been soaked in a saturated Ca(OH)2 solution, while others had not. The carboxymethylated chitin and gellan gum gels have carboxyl groups, while the curdlan gel has hydroxyl groups. None of the gels formed apatite on their surfaces in the SBF when they had not been subjected to the Ca(OH)2 treatment, whereas the carboxymethylated chitin and gellan gum gels formed apatite on their surfaces when they had been subjected to the Ca(OH)2 treatment. The curdlan gel did not form an apatite deposit even after the Ca(OH)2 treatment. Apatite formation on the carboxymethylated chitin and gellan gum gels was attributed to the catalytic effect of their carboxyl groups for apatite nucleation, and acceleration of apatite nucleation from released Ca2+ ions. This result provides a guiding principle for obtaining apatite-organic polymer fiber composites. This composite is expected to have an analogous structure to that of natural bone.

本文言語English
ページ(範囲)2477-2484
ページ数8
ジャーナルBiomaterials
24
14
DOI
出版ステータスPublished - 2003 6
外部発表はい

ASJC Scopus subject areas

  • 生物理学
  • バイオエンジニアリング
  • セラミックおよび複合材料
  • 生体材料
  • 材料力学

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