Antitumour activities of sesquiterpene lactones from Inula helenium and Inula japonica

Yong Li, Zhi Yu Ni, Meng Chu Zhu, Mei Dong, Si Ming Wang, Qing Wen Shi, Man Li Zhang, Yu Fang Wang, Chang Hong Huo, Hiromasa Kiyota, Bin Cong

研究成果: Article査読

29 被引用数 (Scopus)

抄録

Eight sesquiterpene lactones were isolated from the roots of Inula helenium and flowers of I. japonica. Among them, isoalantolactone (3) and santamarine (6) exhibited significant growth inhibitory activities against gynecologic cancer cell lines, while others weakly inhibited the growth of the cell lines (IC50 ≤ 100 μM). In addition, 3 significantly inhibited the tumour growth of S180 tumour-bearing mice. Compounds 3 and 6 were not toxic to human embryonic lung fibroblast cells in vitro. These results demonstrated that the antitumour activities are closely related to the structures of the compounds, that is, an α-exomethylene-γ-lactone ring is necessary for these activities.

本文言語English
ページ(範囲)375-380
ページ数6
ジャーナルZeitschrift fur Naturforschung - Section C Journal of Biosciences
67 C
7-8
DOI
出版ステータスPublished - 2012

ASJC Scopus subject areas

  • 生化学、遺伝学、分子生物学(全般)

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