A novel photosensitizer with both the tumor targetability and magnetic resonance imaging (MRI) activity was designed for efficient photodynamic therapy of tumor. Polyethylene glycol (PEG) was chemically coupled to C60, while a diethylenetriaminepentaacetic acid (DTPA) residue was introduced to the PEG terminal of PEG-C60 prepared. After the DTPA-introduced C 60-PEG was mixed with gadolinium ions (Gd3+) in aqueous solution and injected intravenously into tumor-bearing mice, the MRI and photodynamic activities were investigated. Chelating incorporation of Gd 3+ ions enabled the C60-PEG with tumor targetability to perform the tumor diagnosis and photodynamic therapy simultaneously. This diagnostic and therapeutic hybrid system is a promising tool to enhance the efficacy in photodynamic tumor therapy.
|出版ステータス||Published - 2006|
|イベント||55th SPSJ Annual Meeting - Nagoya, Japan|
継続期間: 2006 5 24 → 2006 5 26
|Other||55th SPSJ Annual Meeting|
|Period||06/5/24 → 06/5/26|
ASJC Scopus subject areas