Antisense activity of 2',4'-BNA targeted to PPAR gamma in THP-1 and HCT116 cells.

Keisuke Tachibana, Tatsuya Katayama, Chihiro Ueda, Mikako Sumitomo, Masayuki Tagami, Kenji Ishimoto, Daisuke Yamasaki, Toshiya Tanaka, Takao Hamakubo, Juro Sakai, Tatsuhiko Kodama, Satoshi Obika, Takeshi Imanishi, Takefumi Doi

研究成果: Article査読

抄録

2'-O,4'-C-methylene bridged nucleic acid (2',4'-BNA) is a nucleic acid analogue that has high affinity binding to its complementary RNA. Peroxisome proliferator-activated receptor (PPAR) y belongs to the nuclear hormone receptor superfamily and is a drug target in the treatment of type 2 diabetes. Here, we show the antisense effects of 2',4'-BNA oligonucleotides against PPARy in the human monocytic leukaemia cell line THP-1 and the human colorectal tumor cell line HCT116.

本文言語English
ページ(範囲)441-442
ページ数2
ジャーナルNucleic acids symposium series (2004)
51
DOI
出版ステータスPublished - 2007
外部発表はい

ASJC Scopus subject areas

  • Medicine(all)

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