Antioxidative and anti-inflammatory actions of reactive cysteine persulfides

Tianli Zhang, Hiroyasu Tsutsuki, Katushiko Ono, Takaaki Akaike, Tomohiro Sawa

研究成果: Review article査読

3 被引用数 (Scopus)


Cysteine persulfide (CysSSH) and polysulfides (CysS[S]nH, n>1) are cysteine derivatives having sulfane sulfur atoms bound to cysteine thiol. Recent advances in the development of analytical methods for detection and quantification of persulfides and polysulfides have revealed the biological presence, in both prokaryotes and eukaryotes, of persulfide/polysulfide in diverse forms such as CysSSH, glutathione persulfide and protein persulfides. Accumu-lating evidence has suggested that persulfide/polysulfide species may involve in a variety of biological events such as biosyntheses of sulfur-containing molecules, tRNA modification, regulation of redox-dependent signal transduction, mitochondrial energy metabolism via sulfur respiration, cytoprotection from oxidative stress via their antioxidant activities, and anti-inflammation against Toll-like receptor-mediated inflammatory responses. Development of chemical sulfur donors may facilitate further understanding of physiological and pathophysiological roles of persulfide/polysulfide species, including regulatory roles of these species in immune responses.

ジャーナルJournal of Clinical Biochemistry and Nutrition
出版ステータスPublished - 2021 1

ASJC Scopus subject areas

  • 医学(その他)
  • 栄養および糖尿病
  • 臨床生化学


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