Antinociceptive effect of different types of calcium channel inhibitors and the distribution of various calcium channel α 1 subunits in the dorsal horn of spinal cord in mice

Manabu Murakami, Osamu Nakagawasai, Takashi Suzuki, Izadi I. Mobarakeh, Yumiko Sakurada, Astunobu Murata, Fumihiro Yamadera, Ichiro Miyoshi, Kazuhiko Yanai, Koichi Tan-No, Hironobu Sasano, Takeshi Tadano, Toshihiko Iijima

研究成果: Article査読

60 被引用数 (Scopus)

抄録

To understand better which voltage-dependent calcium channels (VGCCs) are involved in nociceptive neurotransmission, we investigated the pharmacological properties and distribution of VGCCs in the mouse spinal cord. A behavioral assay revealed that intrathecal injections of ω-agatoxin TK, ω-agatoxin IVA, ω-conotoxin GVIA, and SNX-482, which block P/Q-, P/Q-, N-, and R-type calcium channels, respectively, produced analgesic effects, while an L-type channel blocker had no such effect. An electrophysiological study demonstrated the presence of various types of VGCCs within dorsal root ganglion (DRG) neurons. Immunohistochemistry revealed distinct localization of P/Q-, N-, L-, and R-type calcium channel subunits to the dorsal horn of the spinal cord. The results of this study revealed the localization and functions of several calcium channels that are involved in nociceptive neurotransmission within the dorsal horn of the mouse spinal cord.

本文言語English
ページ(範囲)122-129
ページ数8
ジャーナルBrain research
1024
1-2
DOI
出版ステータスPublished - 2004 10 22

ASJC Scopus subject areas

  • 神経科学(全般)
  • 分子生物学
  • 臨床神経学
  • 発生生物学

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