Antinociceptive effect of cilnidipine, a novel N-type calcium channel antagonist

Manabu Murakami, Osamu Nakagawasai, Shigeo Fujii, Masahiro Hosono, Soichi Hozumi, Akihisa Esashi, Ryoo Taniguchi, Tadashi Okamura, Takashi Suzuki, Hironobu Sasano, Teruyuki Yanagisawa, Koichi Tan-No, Takeshi Tadano, Kenji Kitamura, Kensuke Kisara

研究成果: Article

17 引用 (Scopus)

抜粋

We investigated the antinociceptic effects of cilnidipine, a dihydropyridine derivative which acts on both L- and N-type voltage-dependent calcium channels, in mice. Intrathecally injected cilnidipine showed significant analgesic effect in formalin test. Cilnidipine significantly suppressed N-type currents in dorsal root ganglion (DRG) cells. Our findings apparently support the idea that cilnidipine attenuates synaptic neurotransmission by inhibiting N-type calcium channels in DRG neurons. (C) 2000 Elsevier Science B.V.

元の言語English
ページ(範囲)123-127
ページ数5
ジャーナルBrain research
868
発行部数1
DOI
出版物ステータスPublished - 2000 6 16

ASJC Scopus subject areas

  • Neuroscience(all)
  • Molecular Biology
  • Clinical Neurology
  • Developmental Biology

フィンガープリント Antinociceptive effect of cilnidipine, a novel N-type calcium channel antagonist' の研究トピックを掘り下げます。これらはともに一意のフィンガープリントを構成します。

  • これを引用

    Murakami, M., Nakagawasai, O., Fujii, S., Hosono, M., Hozumi, S., Esashi, A., Taniguchi, R., Okamura, T., Suzuki, T., Sasano, H., Yanagisawa, T., Tan-No, K., Tadano, T., Kitamura, K., & Kisara, K. (2000). Antinociceptive effect of cilnidipine, a novel N-type calcium channel antagonist. Brain research, 868(1), 123-127. https://doi.org/10.1016/S0006-8993(00)02295-2