Antimicrobial and lipopolysaccharide-binding activities of C-terminal domain of human CAP18 peptides to genus Leptospira

Emiko Isogai, Michihisa Hirata, Hiroshi Isogai, Kouki Matsuo, Satoshi Watarai, Hiroko Miura, Keiji Oguma

研究成果: Article査読

3 被引用数 (Scopus)

抄録

Human CAP18 (18-kDa cationic anitimicrobial protein: hCAP18) is a protein originally identified from leukocytes on the basis of its capacity to show antimicrobial activity. We report here that 27-amino acids in C-terminal domain of hCAP18 immobilize and kill Leptospira interrogans and Leptospira biflexa. The domain binds leptopsiral lipopolysaccharide as well as enterobacterial LPS. Analogue peptides also show the activities.

本文言語English
ページ(範囲)180-185
ページ数6
ジャーナルJournal of Applied Research
4
1
出版ステータスPublished - 2004

ASJC Scopus subject areas

  • 薬理学
  • 薬理学(医学)

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「Antimicrobial and lipopolysaccharide-binding activities of C-terminal domain of human CAP18 peptides to genus Leptospira」の研究トピックを掘り下げます。これらがまとまってユニークなフィンガープリントを構成します。

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