Antimicrobial activity of three tick defensins and four mammalian cathelicidin-derived synthetic peptides against lyme disease spirochetes and bacteria isolated from the midgut

Emiko Isogai, Hiroshi Isogai, Koichi Takahashi, Michiko Kobayashi-Sakamoto, Kazuhiko Okumura

研究成果: Article査読

24 被引用数 (Scopus)

抄録

In this study, chemically synthesized tick defensins and cathelicidin-derived mammalian peptides were used to investigate the activity spectrum against Borrelia garinii and symbiotic Stenotrophomonas maltophila. Synthetic tick defensins showed antimicrobial activity against Staphylococcus aureus but not B. garinii and S. maltophila. Mammalian peptides which have cationic property similar to tick defensins, showed antimicrobial activity similar to tick defensins. The antimicrobial peptides in ticks and mammalian hosts have common characteristics against microbial invasion in the innate immune system.

本文言語English
ページ(範囲)221-228
ページ数8
ジャーナルExperimental and Applied Acarology
49
3
DOI
出版ステータスPublished - 2009 10

ASJC Scopus subject areas

  • 生態学
  • 昆虫科学

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