Antimicrobial activity of tea catechin against canine oral bacteria and the functional mechanisms

Lanlan Bai, Shiaki Takagi, Tasuke Ando, Hiroshi Yoneyama, Kumiko Ito, Hiroyuki Mizugai, Emiko Isogai

研究成果: Article査読

25 被引用数 (Scopus)

抄録

Epigallocatechin gallate (EGCG) is the major polyphenolic compound of green tea. Polyphenolic compounds were extracted from the leaf of Camellia sinensis (Japanese green tea), and the minimum inhibitory concentration against canine oral bacteria was measured. Subsequently, we investigated the inhibitory effects of polyphenolic compounds and EGCG on the growth of canine oral bacteria. EGCG showed antimicrobial activity against a model bacterium, Streptococcus mutans. Our results indicate that EGCG can inhibit the growth and biofilm formation of S. mutans and that EGCG does not interact with streptococcal lipoteichoic acid (LTA). Furthermore, our findings suggest that EGCG interacts with other component(s) of the bacterial membrane aside from streptococcal LTA to inhibit biofilm formation and damage biofilms.

本文言語English
ページ(範囲)1439-1445
ページ数7
ジャーナルJournal of Veterinary Medical Science
78
9
DOI
出版ステータスPublished - 2016 9

ASJC Scopus subject areas

  • 獣医学(全般)

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