Antimicrobial activity of a bovine myeloid antimicrobial peptide (BMAP-28) against methicillin-susceptible and methicillin-resistant Staphylococcus aureus

Shiaki Takagi, Shunji Hayashi, Koichi Takahashi, Hiroshi Isogai, Lanlan Bai, Hiroshi Yoneyama, Tasuke Ando, Kumiko Ito, Emiko Isogai

研究成果: Article査読

15 被引用数 (Scopus)

抄録

A bovine myeloid antimicrobial peptide (BMAP-28) is a member of the cathelicidin family which is included in the innate immune system of mammals. Recently, there have been many studies about antimicrobial peptides. This study aims to clarify whether BMAP-28 has bactericidal activity against methicillin-resistant Staphylococcus aureus (MRSA) and compares its activity against methicillin-susceptible S.aureus (MSSA) and MRSA. We found that the peptide was effective in killing MRSA (minimal inhibitory concentration (MIC) range; 5-20μg/mL). It was also revealed that MSSA (MIC range; 1.25-20μg/mL) had two levels of susceptibility to BMAP-28. We also examined the effect of BMAP-28 on bacterial shape to visually show its activity. After exposure to the peptide, both MSSA and MRSA cells showed the morphological changes on their surfaces. Our results indicate that BMAP-28 is a promising candidate for medicine against drug-resistant bacteria.

本文言語English
ページ(範囲)482-486
ページ数5
ジャーナルAnimal Science Journal
83
6
DOI
出版ステータスPublished - 2012 6

ASJC Scopus subject areas

  • 農業および生物科学(全般)

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