Antiischemic properties of fasudil in experimental models of vasospastic angina

S. I. Satoh, I. Ikegaki, T. Asano, H. Shimokawa

研究成果: Article査読

26 被引用数 (Scopus)

抄録

We studied the antiischemic properties of fasudil, a Rho-kinase inhibitor, in conscious rabbits with coronary vasospasm induced by vasopressin and endothelin. Pretreatment with fasudil (0.3 and 3 mg/kg) attenuated the maximum elevation of the T-wave elicited by endothelin. Pretreatment with fasudil inhibited the T-wave elevation elicited by vasopressin. Fasudil and hydroxy fasudil, an active metabolite of fasudil, relaxed the endothelin-, U-46619-, 5-hydroxytryptamine- or histamine-induced contraction in swine coronary arterial strips. Fasudil and hydroxy fasudil significantly prevented the reduction in coronary flow by vasopressin in the Langendorff perfused rat heart. Fasudil was effective in protecting the heart against vasopressin and endothelin-induced myocardial ischemic change in conscious rabbits, and this beneficial effect can be attributed to its action of ameliorating the severe contraction of arteries. The inhibition of Rho-kinase may have implications for the development of novel therapeutic strategies for vasospastic angina in patients.

本文言語English
ページ(範囲)34-40
ページ数7
ジャーナルJapanese Journal of Pharmacology
87
1
DOI
出版ステータスPublished - 2001

ASJC Scopus subject areas

  • 薬理学

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