Antihypertensive peptides derived from bovine casein and whey proteins

Tadao Saito

    研究成果: Article査読

    抄録

    Peptides play an important primary role as a supply of essential amino acids and a source of nitrogen. Recent studies have reported on another role of peptides: having specific amino acid sequences that can express some biological functions in vivo. For an exhaustive study and supply of biologically active peptides, a large-scale screening of protein sources is necessary. Various physiologically functional peptides, such as opioid, immunostimulating, mineral carrier, ACE inhibitory, antihypertensive, and antimicrobial peptides, have been derived from milk protein: both caseins and whey proteins (Meisel, 1998; Korhonen&Pihlanto-Lepp älä , 2001). Milk is known to be a rich source for the supply of bioactive peptides compared to other protein sources such as animal and fish meat, wheat, and soybean proteins. Among the bioactive peptides, ACE inhibitory peptides and antihypertensive peptides have been extensively researched worldwide, because hypertension is a major risk factor in cardiovascular disease, such as heart disease (FitzGerald&Meisel, 2000; Kitts&Weiler, 2003). We discuss the isolation, utilization, and application of bioactive peptides, especially ACE inhibitory peptides and antihypertensive peptides including our recent human studies on their use as a functional food material.

    本文言語English
    ページ(範囲)295-317
    ページ数23
    ジャーナルAdvances in Experimental Medicine and Biology
    606
    DOI
    出版ステータスPublished - 2008

    ASJC Scopus subject areas

    • Biochemistry, Genetics and Molecular Biology(all)
    • Medicine(all)

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