Antigen receptor cross-linking by anti-immunoglobulin antibodies coupled to cell surface membrane induces rapid apoptosis of normal spleen B cells

N. Watanabe, T. Nomura, T. Takai, T. Chiba, T. Honjo, T. Tsubata

研究成果: Article

9 引用 (Scopus)

抜粋

Cross-linking of surface immunoglobulin (sIg) has been shown to induce either activation or apoptosis of mature B cells presumably depending on the nature of antigens. However, the nature of antigens for induction of mature B-cell apoptosis is not yet fully understood. We cross-linked sIg of mature B cells with various amounts of either anti-Ig antibodies in the soluble form or anti-Ig coupled to erythrocytes or myeloma cells as surrogate membrane- bound antigens. Anti-Ig antibodies coupled to cell surface membrane induced rapid and extensive apoptosis of normal spleen B cells even in the absence of signalling via the Fc receptor. In contrast, soluble anti-Ig induced proliferation or apoptosis of mature B cells depending on the concentration of anti-Ig. The extent of apoptosis induced by soluble anti-Ig was limited compared to that induced by membrane-bound anti-Ig. These results suggest that mature B cells undergo apoptosis or proliferation depending on whether antigens are soluble or membrane-bound and on antigen doses.

元の言語English
ページ(範囲)541-547
ページ数7
ジャーナルScandinavian Journal of Immunology
47
発行部数6
DOI
出版物ステータスPublished - 1998 6 25
外部発表Yes

ASJC Scopus subject areas

  • Immunology

フィンガープリント Antigen receptor cross-linking by anti-immunoglobulin antibodies coupled to cell surface membrane induces rapid apoptosis of normal spleen B cells' の研究トピックを掘り下げます。これらはともに一意のフィンガープリントを構成します。

  • これを引用