TY - JOUR
T1 - Antibacterial Activity of Tilmicosin against Pasteurella multocida and Actinobacillus pleuropneumonias Isolated from Pneumonic Lesions in Swine
AU - Inamoto, Tamio
AU - Kikuchi, Katsuaki
AU - Iijima, Hiroaki
AU - Kawashima, Yasunaga
AU - Nakai, Yutaka
AU - Ogimoto, Keiji
N1 - Copyright:
Copyright 2016 Elsevier B.V., All rights reserved.
PY - 1994
Y1 - 1994
N2 - Sixty one strains of Pasteurella multocida and 35 strains of Actinobacillus pleuropneumoniae isolated from pneumonic lesions of porcine lungs during the period from 1985 to 1989 in Japan were tested for antibiotic susceptibility to chlortetracycline (CTC), thiamphenicol (TP), tylosin (TS), acetylisovaleryl-tylosin (AIV-TS), tilmicosin (TMS), mirosamycin (MRM). Most strains of both species were sensitive to CTC, TP and TMS. Growth of fifty-one strains (83.6%) and forty-six strains (75.4%) of P. multocida were inhibited with 3.13 /xg/ml of CTC and 0.78 fig/ml of TP, respectively. TS showed low activity against almost all strains (MIC S 6.25 xg/ml). Fifty-eight (95.1%), twenty-three (37.7%) and fifty (82%) of P. multocida showed MICs of g 6.25 iiglml against AIV-TS, TMS and MRM, respectively. The MICs of A. pleuropneumoniae against CTC were less than 1.56 jug/m/. Thirty-two strains (91.4%) and 33 strains (94.3%) of A. pleuropneumoniae were inhibited with 3.13 g/m/ of TP and TMS respectively. However, TS, AIV-TS and MRM showed low activity against all of A. pleuropneumoniae (MIC i? 6.25 |U,g/m/). Three different resistance patterns were observed in P. multocida and two in A. pleuropneumoniae isolates, respectively.
AB - Sixty one strains of Pasteurella multocida and 35 strains of Actinobacillus pleuropneumoniae isolated from pneumonic lesions of porcine lungs during the period from 1985 to 1989 in Japan were tested for antibiotic susceptibility to chlortetracycline (CTC), thiamphenicol (TP), tylosin (TS), acetylisovaleryl-tylosin (AIV-TS), tilmicosin (TMS), mirosamycin (MRM). Most strains of both species were sensitive to CTC, TP and TMS. Growth of fifty-one strains (83.6%) and forty-six strains (75.4%) of P. multocida were inhibited with 3.13 /xg/ml of CTC and 0.78 fig/ml of TP, respectively. TS showed low activity against almost all strains (MIC S 6.25 xg/ml). Fifty-eight (95.1%), twenty-three (37.7%) and fifty (82%) of P. multocida showed MICs of g 6.25 iiglml against AIV-TS, TMS and MRM, respectively. The MICs of A. pleuropneumoniae against CTC were less than 1.56 jug/m/. Thirty-two strains (91.4%) and 33 strains (94.3%) of A. pleuropneumoniae were inhibited with 3.13 g/m/ of TP and TMS respectively. However, TS, AIV-TS and MRM showed low activity against all of A. pleuropneumoniae (MIC i? 6.25 |U,g/m/). Three different resistance patterns were observed in P. multocida and two in A. pleuropneumoniae isolates, respectively.
KW - Actinobacillus pleuropneumoniae
KW - Pasteurella multocida
KW - antibiotic susceptibility
KW - swine
KW - tilmicosin
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U2 - 10.1292/jvms.56.917
DO - 10.1292/jvms.56.917
M3 - Article
C2 - 7865594
AN - SCOPUS:0028523018
VL - 56
SP - 917
EP - 921
JO - Journal of Veterinary Medical Science
JF - Journal of Veterinary Medical Science
SN - 0916-7250
IS - 5
ER -