Anti-tumor effects of cavitation induced with phase-change nano droplet and ultrasound

Ken Ichi Kawabata, Rei Asami, Takashi Azuma, Hideki Yoshikawa, Shin Ichiro Umemura

研究成果: Conference contribution

抄録

We performed a study to look into the therapeutic application of a novel diagnostic and therapeutic agent, phase change nano droplet (PCND), in combination with 1-MHz ultrasound. It was found using gel phantoms that PCND works as a cavitation accelerator for a 1-MHz ultrasound only when an ultrasound which changes the phase of PCND from liquid to gas (phase change ultrasound) is exposed in advance. A nano droplet that cannot change its phase to a gas does not work even in the presence of the phase change ultrasound. The cavitation induction with the aid of a PCND was observable by B-mode echography as a brightness change. Such a brightness change was also observed in in vivo experiments on tumor baring mice in the presence of a PCND and a phase change ultrasound. Moreover, tissue damage was observed at the site of the brightness change. The lack of either a PCND or a phase change ultrasound did not induce any brightness change, suggesting the same mechanism as a gel phantom works in living tissues. Our results are promising for use in a noble ultrasound therapy system with high selectivity and safety while improving the throughput of current ultrasound tumor treatment systems.

本文言語English
ホスト出版物のタイトル2009 IEEE International Ultrasonics Symposium and Short Courses, IUS 2009
出版社Institute of Electrical and Electronics Engineers Inc.
ページ208-211
ページ数4
ISBN(印刷版)9781424443895
DOI
出版ステータスPublished - 2009
イベント2009 IEEE International Ultrasonics Symposium, IUS 2009 - Rome, Italy
継続期間: 2009 9 202009 9 23

出版物シリーズ

名前Proceedings - IEEE Ultrasonics Symposium
ISSN(印刷版)1051-0117

Other

Other2009 IEEE International Ultrasonics Symposium, IUS 2009
CountryItaly
CityRome
Period09/9/2009/9/23

ASJC Scopus subject areas

  • Acoustics and Ultrasonics

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