Anti-inflammatory properties of red ginger (Zingiber officinale var. Rubra) extract and suppression of nitric oxide production by its constituents

Hiroshi Shimoda, Shao Jie Shan, Junji Tanaka, Azusa Seki, Joung Wook Seo, Naoki Kasajima, Satoru Tamura, Yan Ke, Nobutoshi Murakami

研究成果: Article査読

44 被引用数 (Scopus)

抄録

Red ginger (Zingiber officinale var. Rubra) has been prescribed as an analgesic for arthritis pain in Indonesian traditional medicine. The surface color of the rhizome is purple because of the anthocyanidins in its peel. We prepared 40% ethanolic extract from dried red ginger (red ginger extract [RGE]) and evaluated its anti-inflammatory activity using acute and chronic inflammation models. In an acetic acid-induced mouse writhing model, RGE (10-100mg/kg) suppressed both the frequency of writhing and the increase in permeability of abdominal capillaries. On the other hand, continuous treatment with RGE (10mg/kg) significantly (P<.05) suppressed footpad edema in a rat adjuvant arthritis model. To clarify the anti-inflammatory mechanism of RGE, we examined the effect on prostaglandin (PG) and nitric oxide (NO) production from mouse leukemic monocytes (RAW264 cells) stimulated by lipopolysaccharide. RGE (3 and 10μg/mL) significantly (P<.05) suppressed PGE2 production, while it also suppressed NO production at 100μg/mL. After bioassay-guided separation of RGE, we found that [6]-shogaol and gingerdiols suppressed NO production. Red dye fractions presumed to be proanthocyanidins also suppressed NO production at 100μg/mL. Consequently, we found a potent suppressive effect of RGE on acute and chronic inflammation, and inhibition of macrophage activation seems to be involved in this anti-inflammatory effect. [6]-Shogaol, gingerdiols, and proanthocyanidins were identified as constituents that inhibited NO production.

本文言語English
ページ(範囲)156-162
ページ数7
ジャーナルJournal of Medicinal Food
13
1
DOI
出版ステータスPublished - 2010 2 1

ASJC Scopus subject areas

  • 医学(その他)
  • 栄養および糖尿病

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