Anion sensor-based ratiometric peptide probe for protein kinase activity

Kazuya Kikuchi, Shigeki Hashimoto, Shin Mizukami, Tetsuo Nagano

研究成果: Article査読

29 被引用数 (Scopus)

抄録

A new fluorescent sensor consisting of Cd"-cylcen appended aminocoumarin and a substrate peptide for protein kinase A (PKA) has been designed. Upon phosphorylation by PKA, the metal complex moiety binds to a phosphorylated residue, which In turn displaces the coumarin fluorophore, and this event results In ratiometric change of excitation spectrum In neutral aqueous solution.

本文言語English
ページ(範囲)2732-2735
ページ数4
ジャーナルOrganic letters
11
13
DOI
出版ステータスPublished - 2009 7 2
外部発表はい

ASJC Scopus subject areas

  • Biochemistry
  • Physical and Theoretical Chemistry
  • Organic Chemistry

フィンガープリント 「Anion sensor-based ratiometric peptide probe for protein kinase activity」の研究トピックを掘り下げます。これらがまとまってユニークなフィンガープリントを構成します。

引用スタイル