Animal Models of Vasculitis

Masato Nose

研究成果: Chapter

1 被引用数 (Scopus)

抄録

Animal models of vasculitis have been key to clarifying the mechanisms underlying the development of vasculitis, and models have been generated of the different pathologic prototypes based on cellular, molecular and genetic events. Inductive and reductive trials have been performed to establish vasculitis models, in which the significant roles of immune complexes, the adaptive immunity against vascular components, antineutrophil cytoplasmic antibodies, cytokines, particular infections agents, autoimmunity and polygenes on the development of vasculitis were examined. Further hypothesis generation and testing using animal models will be required to completely elucidate the mechanisms underlying the development, progression and resolution of vasculitis.

本文言語English
ホスト出版物のタイトルInflammatory Diseases of Blood Vessels
ホスト出版物のサブタイトルSecond Edition
出版社Wiley-Blackwell
ページ115-125
ページ数11
ISBN(印刷版)9781444338225
DOI
出版ステータスPublished - 2012 5 3

ASJC Scopus subject areas

  • Medicine(all)

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