Analysis of the p53 gene mutations in patients with multiple primary cancers of the oesophagus

Takato Mayama, Takahiro Mori, Keiji Abe, Hironobu Sasano, Tetsuro Nishihira, Susumu Satomi, Akira Horii

研究成果: Article査読

17 被引用数 (Scopus)

抄録

We investigated genetic alterations of the p53 gene in two patients with multiple primary oesophageal squamous cell carcinomas (ESCs). We found that each primary tumour could be distinguished by mutation of p53. Moreover, mutations detected in the p53 gene in metastatic lymph nodes were the same as those detected in at least one of the primary tumours. Our results presented the possibility of: (1) discrimination of primary and metastatic legions in patients with multiple primary ESCs; (2) determination of metastatic pathway to regional lymph nodes; and (3) application for the development of a better clinical management of patients with multiple primary ESCs.

本文言語English
ページ(範囲)298-303
ページ数6
ジャーナルEuropean Journal of Surgical Oncology
23
4
DOI
出版ステータスPublished - 1997

ASJC Scopus subject areas

  • Surgery
  • Oncology

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