An optical biopsy system with miniaturized raman and spectral imaging probes; in vivo animal and ex vivo clinical application studies

Hidetoshi Sato, Toshiaki Suzuki, Bibin B. Andriana, Shin'ichi Morita, Atsushi Maruyama, Hideyuki Shinzawa, Yuichi Komachi, Gen'ichi Kanai, Nobuo Ura, Koji Masutani, Yuji Matsuura, Masakazu Toi, Toru Shimosegawa, Yukihiro Ozaki

研究成果: Conference article

4 引用 (Scopus)

抜粋

An optical biopsy system which equips miniaturized Raman probes, a miniaturized endoscope and a fluorescent image probe has been developed for in vivo studies of live experimental animals. The present report describes basic optical properties of the system and its application studies for in vivo cancer model animals and ex vivo human cancer tissues. It was developed two types of miniaturized Raman probes, micro Raman probe (MRP) made of optical fibers and ball lens hollow optical fiber Raman probe (BHRP) made of single hollow optical fiber (HOF) with a ball lens. The former has rather large working distance (WD), up to one millimeter. The latter has small WD (∼300μm) which depends on the focal length of the ball lens. Use of multiple probes with different WD allows one to obtain detailed information of subsurface tissues in the totally noninvasive manner. The probe is enough narrow to be inserted into a biopsy needle (∼19G), for observations of the lesion at deeper inside bodies. The miniaturized endoscope has been applied to observe progression of a stomach cancer in the same rat lesion. It was succeeded to visualize structure of non-stained cancer tissue in live model animals by the fluorescent image technique. The system was also applied to ex vivo studies of human breast and stomach cancers.

元の言語English
記事番号71690M
ジャーナルProgress in Biomedical Optics and Imaging - Proceedings of SPIE
7169
DOI
出版物ステータスPublished - 2009
イベントAdvanced Biomedical and Clinical Diagnostic Systems VII - San Jose, CA, United States
継続期間: 2009 1 252009 1 26

ASJC Scopus subject areas

  • Electronic, Optical and Magnetic Materials
  • Biomaterials
  • Atomic and Molecular Physics, and Optics
  • Radiology Nuclear Medicine and imaging

フィンガープリント An optical biopsy system with miniaturized raman and spectral imaging probes; in vivo animal and ex vivo clinical application studies' の研究トピックを掘り下げます。これらはともに一意のフィンガープリントを構成します。

  • これを引用

    Sato, H., Suzuki, T., Andriana, B. B., Morita, S., Maruyama, A., Shinzawa, H., Komachi, Y., Kanai, G., Ura, N., Masutani, K., Matsuura, Y., Toi, M., Shimosegawa, T., & Ozaki, Y. (2009). An optical biopsy system with miniaturized raman and spectral imaging probes; in vivo animal and ex vivo clinical application studies. Progress in Biomedical Optics and Imaging - Proceedings of SPIE, 7169, [71690M]. https://doi.org/10.1117/12.809271