An NDPase links ADAM protease glycosylation with organ morphogenesis in C. elegans

Kiyoji Nishiwaki, Yukihiko Kubota, Yuko Chigira, Samir Kumar Roy, Maho Suzuki, Mara Schvarzstein, Yoshifumi Jigami, Naoki Hisamoto, Kunihiro Matsumoto

    研究成果: Article査読

    45 被引用数 (Scopus)

    抄録

    In the nematode Caenorhabditis elegans, the gonad acquires two U-shaped arms through the directed migration of its distal tip cells (DTCs), which are located at the tip of the growing gonad arms. A member of the ADAM (a disintegrin and metalloprotease) family, MIG-17, regulates directional migration of DTCs: MIG-17 is synthesized and secreted from the muscle cells of the body wall, and diffuses to the gonad where it is required for DTC migration. The mig-23 mutation causes defective migration of DTCs and interacts genetically with mig-17. Here, we report that mig-23 encodes a membrane-bound nucleoside diphosphatase (NDPase) required for glycosylation and proper localization of MIG-17. Our findings indicate that an NDPase affects organ morphogenesis through glycosylation of the MIG-17 ADAM protease.

    本文言語English
    ページ(範囲)31-37
    ページ数7
    ジャーナルNature cell biology
    6
    1
    DOI
    出版ステータスPublished - 2004 1

    ASJC Scopus subject areas

    • 細胞生物学

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