An exon 8-spliced out transcript of neurofibromatosis 2 gene is constitutively expressed in various human tissues

Tsutomu Hitotsumatsu, Tetsuyuki Kitamoto, Toru Iwaki, Masashi Fukui, Jun Tateishi

研究成果: Article

12 引用 (Scopus)

抜粋

We succeeded in cloning the exon 8-spliced out transcript of neurofibromatosis 2 (NF2) gene in human glioma cell lines. We then investigated the expression of the spliced out form in various human tissues by PCR analysis followed by Southern blot hybridization and sequencing to evaluate whether it was generated by normal alternative splicing or by a splicing mutation. The analysis revealed the splicing out of exon 8 in the various tissues, and the transcript missing exon 8 should thus be considered as a product of normal alternative splicing. Our results further support the possibility that the NF2 gene expresses multiple alternatively-spliced transcripts variantly in different tissue types.

元の言語English
ページ(範囲)1205-1207
ページ数3
ジャーナルJournal of biochemistry
116
発行部数6
DOI
出版物ステータスPublished - 1994 1 1
外部発表Yes

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology

フィンガープリント An exon 8-spliced out transcript of neurofibromatosis 2 gene is constitutively expressed in various human tissues' の研究トピックを掘り下げます。これらはともに一意のフィンガープリントを構成します。

  • これを引用