An enantiocontrolled entry to the tricyclic polar segment of (+)-fusarisetin A

Aki Kohyama, Naoki Kanoh, Eunsang Kwon, Yoshiharu Iwabuchi

研究成果: Article査読

7 被引用数 (Scopus)

抄録

The tricyclic polar segment of fusarisetin A, designed for preparing analogues for structure-activity relationship studies of the aliphatic segment thereof, has been constructed in an enantiocontrolled manner, featuring the Yamamoto asymmetric epoxidation of a homoallylic alcohol, C3-selective ring-opening of a 3,4-epoxy alcohol, stereocontrolled merger of a γ-lactone with Garner's counterpart, and ruthenium-catalyzed ring-closing metathesis.

本文言語English
ページ(範囲)517-519
ページ数3
ジャーナルTetrahedron Letters
57
5
DOI
出版ステータスPublished - 2016 2 3

ASJC Scopus subject areas

  • Biochemistry
  • Drug Discovery
  • Organic Chemistry

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