An electrochemical biosensor based on gold microspheres and nanoporous gold for real-time detection of superoxide anion in skeletal muscle tissue

Ramin Banan Sadeghian, Serge Ostrovidov, Sahar Salehi, Jiuhui Han, Mingwei Chen, Ali Khademhosseini

研究成果: Conference contribution

2 被引用数 (Scopus)

抄録

Superoxide anion (SOA) as a member of reactive oxygen species (ROS) group is involved in various physiological and pathological states. For instance, generation of SOA is known to increase with skeletal muscle contractile activity and fatigue. It is therefore important to selectively detect and accurately quantify the release of SOA within both physiological and pathological levels. We report fabrication and characterization of a cytochrome-c functionalized SOA biosensor built on commercially available miniaturized screen-printed electrodes made of gold microspheres. The device was first tested and calibrated in a xanthine/xanthine oxidase (XOD) system and then employed to detect SOA release from C2C12 myoblasts and myotubes upon stimulation with PMA.

本文言語English
ホスト出版物のタイトル2015 37th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2015
出版社Institute of Electrical and Electronics Engineers Inc.
ページ7962-7965
ページ数4
ISBN(電子版)9781424492718
DOI
出版ステータスPublished - 2015 11 4
イベント37th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2015 - Milan, Italy
継続期間: 2015 8 252015 8 29

出版物シリーズ

名前Proceedings of the Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS
2015-November
ISSN(印刷版)1557-170X

Other

Other37th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2015
国/地域Italy
CityMilan
Period15/8/2515/8/29

ASJC Scopus subject areas

  • 信号処理
  • 生体医工学
  • コンピュータ ビジョンおよびパターン認識
  • 健康情報学

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