An electrically resistive sheet of glial cells for amplifying signals of neuronal extracellular recordings

R. Matsumura, H. Yamamoto, M. Niwano, A. Hirano-Iwata

研究成果: Article査読

10 被引用数 (Scopus)

抄録

Electrical signals of neuronal cells can be recorded non-invasively and with a high degree of temporal resolution using multielectrode arrays (MEAs). However, signals that are recorded with these devices are small, usually 0.01%-0.1% of intracellular recordings. Here, we show that the amplitude of neuronal signals recorded with MEA devices can be amplified by covering neuronal networks with an electrically resistive sheet. The resistive sheet used in this study is a monolayer of glial cells, supportive cells in the brain. The glial cells were grown on a collagen-gel film that is permeable to oxygen and other nutrients. The impedance of the glial sheet was measured by electrochemical impedance spectroscopy, and equivalent circuit simulations were performed to theoretically investigate the effect of covering the neurons with such a resistive sheet. Finally, the effect of the resistive glial sheet was confirmed experimentally, showing a 6-fold increase in neuronal signals. This technique feasibly amplifies signals of MEA recordings.

本文言語English
論文番号023701
ジャーナルApplied Physics Letters
108
2
DOI
出版ステータスPublished - 2016 1 11

ASJC Scopus subject areas

  • Physics and Astronomy (miscellaneous)

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