An efficient synthesis of polymer-supported silyl linkers using a di-Grignard reagent

Takayuki Doi, Masahito Yoshida, Ichiro Hijikuro, Takashi Takahashi

研究成果: Article査読

8 被引用数 (Scopus)

抄録

Various trialkylsilyl linked polymer supports have been prepared by reacting benzyl chloride resin and a di-Grignard reagent with CuBr·Me2S, followed by dialkylchlorosilanes. 4-Alkoxybenzyl type resin, Wang-Cl 2c and Argogel Wang-Cl 2d provided 4c and 4d at ambient temperature, whereas nonactivated resin, Merrifield 2a and Argogel-Cl 2b afforded 4a and 4b at 60°C. Primary and secondary alcohols 6-10 were attached to the alkyldiisopropyl-linked Wang type resin 4cA by a novel dehydrosilation with B(C6F5)3 as well as by conventional methods.

本文言語English
ページ(範囲)5723-5726
ページ数4
ジャーナルTetrahedron Letters
45
29
DOI
出版ステータスPublished - 2004 7月 12
外部発表はい

ASJC Scopus subject areas

  • 生化学
  • 創薬
  • 有機化学

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