In recent years, various natural disasters have occurred in various regions of the world. Especially, tsunamis by a big earthquake cause great damage. We have been tackling an evacuation guidance support system by agent-based multi-UAVs for disaster risk reduction. Specifically, software agent generate evacuation guidance plans for UAV, and select the safest plan as the evacuation guidance route considering the disaster situations and the regional characteristics etc. In addition, UAVs provide efficient evacuation guidance support by cooperation of other UAVs. In this paper, we describe the function of selecting the route for UAV and evacuation guidance support by cooperative multi-UAVs. We performed simulation experiments on evacuation guidance based on the safe route selection, and evacuation guidance support by multi-UAVs. Additionally, we also performed an experiment on autonomous flight based on the route selection in real world.