An Atropos Chiral Biphenyl Bisphosphine Ligand Bearing Only 2,2′-Substituents and Its Application in Rh-Catalyzed Asymmetric Hydrogenation

Jia Jia, Zheng Ling, Zhenfeng Zhang, Ken Tamura, Ilya D. Gridnev, Tsuneo Imamoto, Wanbin Zhang

研究成果: Article査読

24 被引用数 (Scopus)

抄録

An atropos chiral biphenyl bisphosphine ligand bearing only 2,2′-substituents was rationally designed and easily synthesized utilizing a bulky chiral t-butylmethylphosphino block. Computational results showed a large difference in the free energies between the two diastereomers (7.8 kcal/mol) and attainable rotational energy barriers from one diastereomer to another (27.7 kcal/mol and reverse 19.9 kcal/mol). This ligand avoids the time-consuming optical resolution generally needed for the preparation of axially chiral ligands and shows high reactivity and enantioselectivity in Rh-catalyzed asymmetric hydrogenations. (Figure presented.).

本文言語English
ページ(範囲)738-743
ページ数6
ジャーナルAdvanced Synthesis and Catalysis
360
4
DOI
出版ステータスPublished - 2018 2月 15

ASJC Scopus subject areas

  • 触媒
  • 有機化学

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