An analysis of potential surrogate markers of target-specific therapy in archival materials of adrenocortical carcinoma

Megumi Nakamura, Yasuhiro Miki, Jun Ichi Akahira, Ryo Morimoto, Fumitoshi Satoh, Shigeto Ishidoya, Yoichi Arai, Takashi Suzuki, Yutaka Hayashi, Hironobu Sasano

研究成果: Article査読

17 被引用数 (Scopus)

抄録

Adrenocortical carcinoma (ACC) is a rare neoplasm but some of the cases are highly malignant. Clinical outcome of the patients with advanced ACC still remained poor or dismal despite recent development of aggressive antitumor therapies. Target-specific therapies have been developed in a number of human malignancies and resulted in therapeutic benefits in some cancer patients. However, these therapies are only effective in the cases in which corresponding targets are expressed in tumor tissues. Therefore, we evaluated expression of potential surrogate markers using immunohistochemistry in archival materials of adrenocortical carcinoma in order to explore the potential application of target specific therapies in ACC in this study. We immunolocalized ten established or potential surrogate markers of target-specific therapies, located in the Ras/ extracellular signal-regulated kinase and phosphatidylinosi-tol-3 kinase/Akt pathways, in 41 ACC cases, 54 adreno-cortical adenoma (ACA) cases, and five nonpathological adrenal glands and correlated the findings with clinicopath-ological factors of the patients. Among these markers examined, only epidermal growth factor receptor (EGFR) was significantly more abundant in ACC than in ACA (P< 0.01). These findings suggest that the agents which specifically inhibit signal transductions through EGFR such as monoclonal antibodies against EGFR are considered to be worthwhile to be attempted in future clinical studies.

本文言語English
ページ(範囲)17-23
ページ数7
ジャーナルEndocrine Pathology
20
1
DOI
出版ステータスPublished - 2009 3

ASJC Scopus subject areas

  • 病理学および法医学
  • 内分泌学、糖尿病および代謝内科学
  • 内分泌学

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