TY - JOUR
T1 - Ampelopsins E, E, H and cis-ampelopsin E, oligostilbenes from Ampelopsis brevipedunculata var. Hancei roots
AU - Oshima, Yoshiteru
AU - Ueno, Yuji
PY - 1993/4/29
Y1 - 1993/4/29
N2 - The methanol extract of the roots of Ampelopsis brevipedunculata var. hancei exhibited marked protective activity against carbon tetrachloride and d-galactosamine-induced liver damage in primary cultured rat hepatocytes. The extract was fractionated by monitoring the activity to give active fractions from which four novel oxidative oligostilbenes, ampelopsins D, E, H and cis-ampelopsin E, were isolated in addition to the known compounds, (-)-epicatechin, pallidol, miyabenol C, piceid, cis-piceid and resveratroloside. The structures of the new stilbene derivatives have been established on the basis of spectroscopic evidence and chemical reactions. Among them, ampelopsin E and cis-ampelopsin E showed antihepatotoxic activity.
AB - The methanol extract of the roots of Ampelopsis brevipedunculata var. hancei exhibited marked protective activity against carbon tetrachloride and d-galactosamine-induced liver damage in primary cultured rat hepatocytes. The extract was fractionated by monitoring the activity to give active fractions from which four novel oxidative oligostilbenes, ampelopsins D, E, H and cis-ampelopsin E, were isolated in addition to the known compounds, (-)-epicatechin, pallidol, miyabenol C, piceid, cis-piceid and resveratroloside. The structures of the new stilbene derivatives have been established on the basis of spectroscopic evidence and chemical reactions. Among them, ampelopsin E and cis-ampelopsin E showed antihepatotoxic activity.
KW - Ampelopsis brevipedunculata
KW - Vitaceae
KW - ampelopsins D, E, H, cis-ampelopsin E
KW - antihepatotoxic activity
KW - oligostilbenes
KW - primary cultured rat hepatocytes.
KW - roots
KW - wild vine
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U2 - 10.1016/0031-9422(93)85418-Q
DO - 10.1016/0031-9422(93)85418-Q
M3 - Article
AN - SCOPUS:0000692525
VL - 33
SP - 179
EP - 182
JO - Phytochemistry
JF - Phytochemistry
SN - 0031-9422
IS - 1
ER -