Amino acid adducts of PAH o-quinones: Model studies with naphthalene-1,2-dione

Gopishetty R. Sridhar, Varanasi S. Murty, Seon Hwa Lee, Ian A. Blair, Trevor M. Penning

研究成果: Article査読

9 被引用数 (Scopus)

抄録

Polycyclic aromatic hydrocarbons (PAHs) are environmental pollutants which may cause cancer and require metabolic activation to exert their carcinogenic effects. As a step toward identifying the spectrum of PAH o-quinone-amino acid adducts that may form in biological systems, several naphthalene-1,2-dione-amino acid adducts were synthesized. Each adduct was formed as a 1,4-Michael addition product and spectral data corroborate that these adducts were either o-quinones or catechols. PAH o-quinone adducts can be used as standards to identify their presence in vitro and in vivo.

本文言語English
ページ(範囲)407-412
ページ数6
ジャーナルTetrahedron
57
2
DOI
出版ステータスPublished - 2001 1 7
外部発表はい

ASJC Scopus subject areas

  • 生化学
  • 創薬
  • 有機化学

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