TY - JOUR
T1 - AlzPathway, an updated map of curated signaling pathways
T2 - Towards deciphering Alzheimer’s disease pathogenesis
AU - Ogishima, Soichi
AU - Mizuno, Satoshi
AU - Kikuchi, Masataka
AU - Miyashita, Akinori
AU - Kuwano, Ryozo
AU - Tanaka, Hiroshi
AU - Nakaya, Jun
N1 - Publisher Copyright:
© Springer Science+Business Media New York 2016.
PY - 2016
Y1 - 2016
N2 - Alzheimer’s disease (AD) is a complex neurodegenerative disorder in which loss of neurons and synaptic function causes dementia in the elderly. To clarify AD pathogenesis and develop drugs for AD, thousands of studies have elucidated signaling pathways involved. However, knowledge of AD signaling pathways has not been compiled as a pathway map. In this chapter, we introduce the manual construction of a pathway map in AD which we call “AlzPathway”, that comprehensively catalogs signaling pathways in the field of AD. We have collected and manually curated over 100 review articles related to AD, and have built the AD pathway map. AlzPathway is currently composed of thousands of molecules and reactions in neurons, brain blood barrier, presynaptic, postsynaptic, astrocyte, and microglial cells, with their cellular localizations. AlzPathway provides a systems-biology platform of comprehensive AD signaling and related pathways which is expected to contribute to clarification of AD pathogenesis and AD drug development.
AB - Alzheimer’s disease (AD) is a complex neurodegenerative disorder in which loss of neurons and synaptic function causes dementia in the elderly. To clarify AD pathogenesis and develop drugs for AD, thousands of studies have elucidated signaling pathways involved. However, knowledge of AD signaling pathways has not been compiled as a pathway map. In this chapter, we introduce the manual construction of a pathway map in AD which we call “AlzPathway”, that comprehensively catalogs signaling pathways in the field of AD. We have collected and manually curated over 100 review articles related to AD, and have built the AD pathway map. AlzPathway is currently composed of thousands of molecules and reactions in neurons, brain blood barrier, presynaptic, postsynaptic, astrocyte, and microglial cells, with their cellular localizations. AlzPathway provides a systems-biology platform of comprehensive AD signaling and related pathways which is expected to contribute to clarification of AD pathogenesis and AD drug development.
KW - AlzPathway
KW - Alzheimer’s disease
KW - Drug discovery
KW - Manual curation
KW - Pathway map
KW - Signaling pathway
KW - Systems biology
UR - http://www.scopus.com/inward/record.url?scp=84938630425&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84938630425&partnerID=8YFLogxK
U2 - 10.1007/978-1-4939-2627-5_25
DO - 10.1007/978-1-4939-2627-5_25
M3 - Article
C2 - 26235082
AN - SCOPUS:84938630425
VL - 1303
SP - 423
EP - 432
JO - Methods in Molecular Biology
JF - Methods in Molecular Biology
SN - 1064-3745
ER -