Alzheimer's amyloid precursor protein accumulates within axonal swellings in human brain lesions

Tetsuya Ohgami, Tetsuyuki Kitamoto, Jun Tateishi

研究成果: Article査読

63 被引用数 (Scopus)

抄録

By using a monoclonal antibody and polyclonal antibodies to human β amyloid precursor protein (APP), we immunohistochemically examined axonal swellings (spheroids). The immunoreactivity of APP was observed in numerous spheroids, which were found around the areas of old cerebral infarctions, in the globus pallidus with Hallervorden-Spatz disease as well as in or around brain abscesses. The axonal swellings were not immunolabeled with β protein. These results implied that APP accumulated in spheroids regardless of β protein depositions.

本文言語English
ページ(範囲)75-78
ページ数4
ジャーナルNeuroscience Letters
136
1
DOI
出版ステータスPublished - 1992 2 17
外部発表はい

ASJC Scopus subject areas

  • Neuroscience(all)

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