Altered urinary profiles of polyamines and endogenous steroids in patients with benign cervical disease and cervical cancer

Seon Hwa Lee, Yoon Jung Yang, Kyung Mee Kim, Bong Chul Chung

研究成果: Article査読

33 被引用数 (Scopus)

抄録

The risk of cancer of the cervix is linked with sexual behavior. Although infectious agents, such as human papillomaviruses (HPVs) are implicated, these alone may be insufficient to induce the disease. We investigated the potential role of estrogen, androgen, and polyamine metabolism as co-factors in the development of cervical cancer. We obtained urine samples from patients with benign cervical disease (n=18) and cervical cancer (n=18) and from age-matched normal female subjects (n=25). For 11 polyamine determination, an improved and sensitive gas-chromatographic with nitrogen/phosphorus-detection (GC/NPD) procedure was used. The urinary levels of 25 androgens and corticoids and 16 estrogens were quantitatively determined by gas chromatography-mass spectrometry-selected ion-monitoring (GC/MS/SIM). In the patients with cervical cancer, the ratio of 16α-hydroxy estrone (16α-OH E1)/2-hydroxy estrone (2-OH E1), putrescine (Put)/N1-acetylspermidine (N 1-acSpd) and 5β-tetrahydrocortisol (THF)/5α- tetrahydrocortisol (5α-THF) were significantly increased in comparison to the values of the normal controls. These data suggest: (1) an increase of 16α-hydroxylation in estrogen metabolism; (2) the high activity of polyamine oxidase (PAO) in polyamine metabolism; and (3) the low activity of 5α-reductase in androgen metabolism may play a significant role in the development of cervical cancer. Although additional research is necessary, the combination of 16α-OH E1/2-OH E1 and THF/5α-THF may provide a dual marker for the discrimination of benign cervical disease and cervical cancer.

本文言語English
ページ(範囲)121-131
ページ数11
ジャーナルCancer Letters
201
2
DOI
出版ステータスPublished - 2003 11 14
外部発表はい

ASJC Scopus subject areas

  • 腫瘍学
  • 癌研究

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