Background: Cytokines play an important role in mediating inflammatory-proliferative responses, including atherosclerosis. Alterations in the plasma levels of cytokines in patients with ischemic heart disease (IHD) remain to be examined. Objective: To examine the possible alterations in the plasma levels of cytokines in patients with IHD and in controls. Methods: Thirty-one patients with IHD and 16 controls were studied. The cytokines measured in our study included interleukin-6, macrophage-colony-stimulating factor (MCSF), transforming growth factor-β (TGF-β), and seven other major cytokines. The measurements were performed by using an enzyme-linked immunosorbent assay method. Results: The MCSF levels were significantly higher in patients with IHD than they were in controls (P < 0.01), whereas the TGF-β levels were significantly lower in patients with IHD than they were in controls (P < 0.01). Moreover, the levels of MCSF and those of TGF-β were correlated negatively (P < 0.05). The interleukin-6 levels tended to be higher in patients with unstable angina. The plasma levels of other cytokines were below the detection levels in most cases. Conclusions: Results from studies in vitro suggested that the process of atherosclerosis is accelerated and inhibited by MCSF and TGF-β, respectively. The present results thus suggest that the alterations in the plasma levels of MCSF and TGF-β may be involved in the pathogenesis of IHD in humans.
|ジャーナル||Coronary Artery Disease|
|出版ステータス||Published - 1997 7 17|
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