Alteration of hepatic sulfation by endotoxin

Miki Shimada, Eriko Watanabe, Yuka Iida, Kiyoshi Nagata, Yasushi Yamazoe

    研究成果: Article査読

    8 被引用数 (Scopus)

    抄録

    Administration of an endotoxin, lipopolysaccharide (1 mg/kg body weight), caused decreases in hepatic sulfations of xenobiotics in male rats through changes in the amounts of at least three forms of sulfotransferases, ST1A1, ST1B1 and ST1C1. The time-dependent decrease was first observed with ST1B1, followed by ST1A1 and ST1C1; and the decrease was more profound in the levels of mRNAs than those of proteins. The decreases in their mRNAs were, however, prevented by the pretreatment with dexamethasone. These results suggest that the endotoxin suppresses the hepatic sulfation through a cytokine-mediated mechanism to change individually hepatic levels of ST1A1, ST1B1 and ST1C1.

    本文言語English
    ページ(範囲)371-373
    ページ数3
    ジャーナルJapanese Journal of Pharmacology
    80
    4
    DOI
    出版ステータスPublished - 1999

    ASJC Scopus subject areas

    • 薬理学

    フィンガープリント

    「Alteration of hepatic sulfation by endotoxin」の研究トピックを掘り下げます。これらがまとまってユニークなフィンガープリントを構成します。

    引用スタイル