Alteration of genome structure induced by very low dose-rate irradiation in mouse tissues

Tetsuya Ono; Yoshihiko Uehara; Naohito Okudaira; Kazuo Fujikawa; Nao Kagawa; Mitsuaki Yoshida; Isamu Hayata; Takehiko Nohmi; Tsuneya Matsumoto; Yoichi Oghiso; Kimio Tanaka; Kazuaki Ichinohe; Shingo Nakamura; Satoshi Tanaka

doi:10.2481/dsj.BR-05

Alteration of genome structure induced by very low dose-rate irradiation in mouse tissues

Tetsuya Ono, Yoshihiko Uehara, Naohito Okudaira, Kazuo Fujikawa, Nao Kagawa, Mitsuaki Yoshida, Isamu Hayata, Takehiko Nohmi, Tsuneya Matsumoto, Yoichi Oghiso, Kimio Tanaka, Kazuaki Ichinohe, Shingo Nakamura, Satoshi Tanaka

研究成果: Article › 査読

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To understand the effects of low dose-rate radiation on genome structure in vivo, we examined gene mutation and chromosomal abnormality in mouse tissues. The mutation was studied on transgenes in the spleen and liver and also on the Dlb1 gene in intestinal stem cells. The mice were irradiated for 483 consecutive days at three dose-rates of 0.0323, 0.65, and 12.5 μGy/min, which resulted in total doses of 21, 414, and 8,000 mGy, respectively. Statistically significant increases were observed for all indices examined when the total dose was 8,000 mGy, whereas no significant difference was observed with 21 mGy or 414 mGy.

本文言語	English
ページ（範囲）	BR36-BR41
ジャーナル	Data Science Journal
巻	8
DOI	https://doi.org/10.2481/dsj.BR-05
出版ステータス	Published - 2009 9月 24
外部発表	はい

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title = "Alteration of genome structure induced by very low dose-rate irradiation in mouse tissues",

abstract = "To understand the effects of low dose-rate radiation on genome structure in vivo, we examined gene mutation and chromosomal abnormality in mouse tissues. The mutation was studied on transgenes in the spleen and liver and also on the Dlb1 gene in intestinal stem cells. The mice were irradiated for 483 consecutive days at three dose-rates of 0.0323, 0.65, and 12.5 μGy/min, which resulted in total doses of 21, 414, and 8,000 mGy, respectively. Statistically significant increases were observed for all indices examined when the total dose was 8,000 mGy, whereas no significant difference was observed with 21 mGy or 414 mGy.",

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T1 - Alteration of genome structure induced by very low dose-rate irradiation in mouse tissues

AU - Ono, Tetsuya

AU - Uehara, Yoshihiko

AU - Okudaira, Naohito

AU - Fujikawa, Kazuo

AU - Kagawa, Nao

AU - Yoshida, Mitsuaki

AU - Hayata, Isamu

AU - Nohmi, Takehiko

AU - Matsumoto, Tsuneya

AU - Oghiso, Yoichi

AU - Tanaka, Kimio

AU - Ichinohe, Kazuaki

AU - Nakamura, Shingo

AU - Tanaka, Satoshi

PY - 2009/9/24

Y1 - 2009/9/24

N2 - To understand the effects of low dose-rate radiation on genome structure in vivo, we examined gene mutation and chromosomal abnormality in mouse tissues. The mutation was studied on transgenes in the spleen and liver and also on the Dlb1 gene in intestinal stem cells. The mice were irradiated for 483 consecutive days at three dose-rates of 0.0323, 0.65, and 12.5 μGy/min, which resulted in total doses of 21, 414, and 8,000 mGy, respectively. Statistically significant increases were observed for all indices examined when the total dose was 8,000 mGy, whereas no significant difference was observed with 21 mGy or 414 mGy.

AB - To understand the effects of low dose-rate radiation on genome structure in vivo, we examined gene mutation and chromosomal abnormality in mouse tissues. The mutation was studied on transgenes in the spleen and liver and also on the Dlb1 gene in intestinal stem cells. The mice were irradiated for 483 consecutive days at three dose-rates of 0.0323, 0.65, and 12.5 μGy/min, which resulted in total doses of 21, 414, and 8,000 mGy, respectively. Statistically significant increases were observed for all indices examined when the total dose was 8,000 mGy, whereas no significant difference was observed with 21 mGy or 414 mGy.

KW - Chromosomal abnormality

KW - Low dose-rate

KW - Mouse

KW - Mutation

KW - Radiation

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SP - BR36-BR41

JO - Data Science Journal

JF - Data Science Journal

ER -

Alteration of genome structure induced by very low dose-rate irradiation in mouse tissues

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