Alteration of c-fos gene methylation in human gliomas

Shinji Uyeno; Jun Ichiro Komura; Riichi Tawa; Yasuhiro Aoki; Masayuki Nata; Hironobu Sasano; Hiroshi Nakura; Kaoru Sagisaka; Hiromu Sakurai; Takamasa Kayama; Takashi Yoshimoto; Tetsuya Ono

doi:10.1002/(SICI)1098-2744(199606)16:2<91::AID-MC5>3.0.CO;2-Q

Alteration of c-fos gene methylation in human gliomas

Shinji Uyeno, Jun Ichiro Komura, Riichi Tawa, Yasuhiro Aoki, Masayuki Nata, Hironobu Sasano, Hiroshi Nakura, Kaoru Sagisaka, Hiromu Sakurai, Takamasa Kayama, Takashi Yoshimoto, Tetsuya Ono

医学系研究科・医科学専攻

研究成果: Article › 査読

6 被引用数 (Scopus)

抄録

In an attempt to find a common DNA alteration occurring in human glioma, we examined DNA methylation in 34 gliomas of various pathological grades and compared them with those in normal cerebral subcortex DNA. The total methylated cytosine levels in the genome did not differ appreciably between the tumors and the normal tissues; however, the degree of DNA methylation in several proto-oncogenes and suppressor oncogenes showed some alterations. Among them, the c-fos gene demonstrated deviation from that of normal tissues in all cases examined, suggesting that the alteration of c-fos gene methylation plays a role in the early steps of human glioma development.

本文言語	English
ページ（範囲）	91-100
ページ数	10
ジャーナル	Molecular Carcinogenesis
巻	16
号	2
DOI	https://doi.org/10.1002/(SICI)1098-2744(199606)16:2<91::AID-MC5>3.0.CO;2-Q
出版ステータス	Published - 1996 6月

ASJC Scopus subject areas

分子生物学
癌研究

UN SDG

この成果は、次の持続可能な開発目標に貢献しています

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10.1002/(SICI)1098-2744(199606)16:2<91::AID-MC5>3.0.CO;2-Q

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title = "Alteration of c-fos gene methylation in human gliomas",

abstract = "In an attempt to find a common DNA alteration occurring in human glioma, we examined DNA methylation in 34 gliomas of various pathological grades and compared them with those in normal cerebral subcortex DNA. The total methylated cytosine levels in the genome did not differ appreciably between the tumors and the normal tissues; however, the degree of DNA methylation in several proto-oncogenes and suppressor oncogenes showed some alterations. Among them, the c-fos gene demonstrated deviation from that of normal tissues in all cases examined, suggesting that the alteration of c-fos gene methylation plays a role in the early steps of human glioma development.",

keywords = "DNA methylation, Human glioma, Proto-oncogene, Suppressor oncogene, c-fos",

author = "Shinji Uyeno and Komura, {Jun Ichiro} and Riichi Tawa and Yasuhiro Aoki and Masayuki Nata and Hironobu Sasano and Hiroshi Nakura and Kaoru Sagisaka and Hiromu Sakurai and Takamasa Kayama and Takashi Yoshimoto and Tetsuya Ono",

year = "1996",

month = jun,

doi = "10.1002/(SICI)1098-2744(199606)16:2<91::AID-MC5>3.0.CO;2-Q",

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AU - Uyeno, Shinji

AU - Komura, Jun Ichiro

AU - Tawa, Riichi

AU - Aoki, Yasuhiro

AU - Nata, Masayuki

AU - Sasano, Hironobu

AU - Nakura, Hiroshi

AU - Sagisaka, Kaoru

AU - Sakurai, Hiromu

AU - Kayama, Takamasa

AU - Yoshimoto, Takashi

AU - Ono, Tetsuya

PY - 1996/6

Y1 - 1996/6

N2 - In an attempt to find a common DNA alteration occurring in human glioma, we examined DNA methylation in 34 gliomas of various pathological grades and compared them with those in normal cerebral subcortex DNA. The total methylated cytosine levels in the genome did not differ appreciably between the tumors and the normal tissues; however, the degree of DNA methylation in several proto-oncogenes and suppressor oncogenes showed some alterations. Among them, the c-fos gene demonstrated deviation from that of normal tissues in all cases examined, suggesting that the alteration of c-fos gene methylation plays a role in the early steps of human glioma development.

AB - In an attempt to find a common DNA alteration occurring in human glioma, we examined DNA methylation in 34 gliomas of various pathological grades and compared them with those in normal cerebral subcortex DNA. The total methylated cytosine levels in the genome did not differ appreciably between the tumors and the normal tissues; however, the degree of DNA methylation in several proto-oncogenes and suppressor oncogenes showed some alterations. Among them, the c-fos gene demonstrated deviation from that of normal tissues in all cases examined, suggesting that the alteration of c-fos gene methylation plays a role in the early steps of human glioma development.

KW - DNA methylation

KW - Human glioma

KW - Proto-oncogene

KW - Suppressor oncogene

KW - c-fos

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AN - SCOPUS:8944258565

SN - 0899-1987

VL - 16

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JO - Molecular Carcinogenesis

JF - Molecular Carcinogenesis

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Alteration of c-fos gene methylation in human gliomas

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ASJC Scopus subject areas

UN SDG

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