Alteration of c-fos gene methylation in human gliomas

Shinji Uyeno, Jun Ichiro Komura, Riichi Tawa, Yasuhiro Aoki, Masayuki Nata, Hironobu Sasano, Hiroshi Nakura, Kaoru Sagisaka, Hiromu Sakurai, Takamasa Kayama, Takashi Yoshimoto, Tetsuya Ono

研究成果: Article査読

6 被引用数 (Scopus)

抄録

In an attempt to find a common DNA alteration occurring in human glioma, we examined DNA methylation in 34 gliomas of various pathological grades and compared them with those in normal cerebral subcortex DNA. The total methylated cytosine levels in the genome did not differ appreciably between the tumors and the normal tissues; however, the degree of DNA methylation in several proto-oncogenes and suppressor oncogenes showed some alterations. Among them, the c-fos gene demonstrated deviation from that of normal tissues in all cases examined, suggesting that the alteration of c-fos gene methylation plays a role in the early steps of human glioma development.

本文言語English
ページ(範囲)91-100
ページ数10
ジャーナルMolecular Carcinogenesis
16
2
DOI
出版ステータスPublished - 1996 6

ASJC Scopus subject areas

  • Molecular Biology
  • Cancer Research

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