Alteration in aortic wall stiffness and accumulation of collagen during the prediabetic stage of type II diabetes mellitus in rats

Takahisa Noma, Katsufumi Mizushige, Li Yao, Yang Yu, Hideyasu Kiyomoto, Naohisa Hosomi, Shoji Kimura, Youichi Abe, Koji Ohmori, Hirohide Matsuo

研究成果: Article査読

19 被引用数 (Scopus)

抄録

Aortic damage during the prediabetic stage of diabetes mellitus (DM) was investigated in Otsuka Long-Evans Tokushima Fatty (OLETF) rats, as an animal model of type II DM. In 30 OLETF and 30 nonDM rats, an oral glucose tolerance test was performed at 10, 20 and 30 weeks of age. At 15 and 30 weeks, intravascular ultrasound images and aortic pressure were recorded and the stiffness parameter β was calculated. The aortic walls were excised at 5, 15 and 30 weeks for histopathology and the measurement of hydroxyproline. At 10 weeks, blood glucose (mg/dl) and insulin concentrations (ng/ml) of the OLETF rats (2h; 168±30 and 0.82±0.1.5) were significantly high (nonDM: 118±15; p=0.02 and 0.16±0.64; p=0.003). At the prediabetic stage (15 weeks), β in the OLETF rats (2.5±0.9) was larger than in nonDM rats (1.4±0.4; p=0.0006), and the collagen (hydroxyproline) content/dry weight (mg/g) of the aortic wall was significantly higher in OLETF (33.5±3.1) than in nonDM rats (28.7±3.5; p<.05). Histopathological examination showed that from 15 weeks of age the medial wall thickness increased gradually. In the prediabetic stage, collagen accumulation may contribute to impairment of aortic wall stiffness in the OLETF rats, which would accelerate the aging process in the aortic wall.

本文言語English
ページ(範囲)988-993
ページ数6
ジャーナルJAPANESE CIRCULATION JOURNAL
63
12
DOI
出版ステータスPublished - 1999 12

ASJC Scopus subject areas

  • 生理学
  • 循環器および心血管医学

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