Alkoxyacetyl (AAc) group as a useful linker for organic synthesis on poly(ethylene glycol) support

Masato Oikawa, Minoru Ikoma, Makoto Sasaki

研究成果: Article査読

12 被引用数 (Scopus)

抄録

An alkoxyacetyl group (AAc) group was found to be an efficient linker for high-throughput synthesis of small molecules on a soluble polymer support. The linker allows high-yield loading of alcohols and phenols either by conventional carbodiimide-mediated esterification or transesterification using Yb(OTf) 3. Chemoselective cleavage to release small molecules is attained also by Yb(OTf)3 or TMSCHN2. The preparation, protocols for loading and releasing of small molecules, and an application to the Ugi four-component coupling reaction are reported.

本文言語English
ページ(範囲)2371-2375
ページ数5
ジャーナルTetrahedron Letters
45
11
DOI
出版ステータスPublished - 2004 2 8

ASJC Scopus subject areas

  • 生化学
  • 創薬
  • 有機化学

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