Alcohol consumption and the risk for developing pancreatitis: A case-control study in Japan

Kiyoshi Kume, Atsushi Masamune, Hiroyuki Ariga, Tooru Shimosegawa

研究成果: Article査読

16 被引用数 (Scopus)

抄録

Objective: This study aimed to estimate the association of alcohol consumption and pancreatitis in Japan. Methods:We performed a nationwide case-control study,which included 982 patients (574 patients with acute pancreatitis and 408 patients with chronic pancreatitis) and 1015 controls who were individually matched for sex, age, hospital, and time of their first hospital visit. Conditional logistic regression was used to assess the association of alcohol consumption and smoking with pancreatitis. Results: The patients had a mean (SD) age of 57.6 (17.0) years; 71.8% were male. Compared with nondrinkers, alcohol consumption of less than 20 g/d was not associated with the risk for total pancreatitis (odds ratio [OR], 1.0; 95% confidence interval [CI], 0.7-1.4). In patients with acute pancreatitis, the ORs (95% CI) for alcohol consumption of 20 ≤ ∼ < 40 g/d, 40≤∼< 60 g/d, 60≤∼< 80 g/d, 80≤∼< 100 g/d, and 100 g/d or greater were 1.7 (0.9-3.0), 3.1 (1.6-5.9), 4.2 (2.1-8.2), 5.3 (2.4-12.0), and 6.4 (3.4-12.4), respectively. In patients with chronic pancreatitis, the ORs (95% CI) for alcohol consumption of 20 ≤ ∼ < 40 g/d, 40 ≤ ∼ < 60 g/d, 60 ≤ ∼ < 80 g/d, 80 ≤ ∼ < 100 g/d, and 100 g/d or greater were 2.6 (1.2-5.5), 3.2 (1.5-7.1), 9.2 (4.1-20.3), 13.0 (5.3-31.6), and 19.6 (8.2-46.8), respectively. Conclusions: Our study precisely measured the quantitative effect of alcohol on the risk for developing pancreatitis.

本文言語English
ページ(範囲)53-58
ページ数6
ジャーナルPancreas
44
1
DOI
出版ステータスPublished - 2015 1

ASJC Scopus subject areas

  • 内科学
  • 内分泌学、糖尿病および代謝内科学
  • 肝臓学
  • 内分泌学

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