9 被引用数 (Scopus)

抄録

Dual surface immunoglobulin light-chain expression in B-cell malignant neoplasm is a rare event, and has been predominantly reported in chronic lymphocytic leukemia. Herein, we report a case of aggressive B-cell lymphoma with κ/λ-dual surface immunoglobulin light-chain expression of a 69-year-old woman. The lymphoma cells were positive for CD5, CD19, CD20, HLA-DR, Igκ and Igλ. Southern blot analysis confirmed rearranged bands for both light chains with a monoclonal heavy chain rearrangement. She was treated with a combination of rituximab and CHOP regimen, but died of the progressive disease. To our knowledge, this is the first case of aggressive B-cell lymphoma showing dual κ/λ expression; the possible mechanisms of abnormal light chain expression are discussed.

本文言語English
ページ(範囲)1458-1461
ページ数4
ジャーナルInternal Medicine
46
17
DOI
出版ステータスPublished - 2007 9 3

ASJC Scopus subject areas

  • 内科学

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