Age-related clinicopathologic and molecular features of patients receiving curative hepatectomy for hepatocellular carcinoma

Eriko Katsuta, Shinji Tanaka, Kaoru Mogushi, Satoshi Matsumura, Daisuke Ban, Takanori Ochiai, Takumi Irie, Atsushi Kudo, Noriaki Nakamura, Hiroshi Tanaka, Minoru Tanabe, Shigeki Arii

研究成果: Article査読

13 被引用数 (Scopus)

抄録

Background Age-related differences of clinicopathologic features, outcomes, and molecular properties of hepatocellular carcinoma remain unclarified. Methods We classified patients who underwent hepatectomy for hepatocellular carcinoma into 3 groups by age bracket; younger group (<50 years), middle-aged group (50 to 79 years), and elderly group (≥80 years) and compared age-related features. Results Hepatitis viral infection was dominant in the younger group (hepatitis B virus [HBV]; 67%) and middle-aged group (hepatitis C virus [HCV]; 56%), whereas the elderly group showed a significantly higher rate without hepatitis virus infection (absence of HBV and HCV infection, 66%; P =.0001). There was a significantly greater proportion of age-associated pre-existing comorbidity in the elderly group (89%; P =.0004). Liver cirrhosis in the elderly group (24%) was significantly lower than other groups (younger, 67%; middle-aged, 50%; P =.0058). There was no significant difference in perioperative and postoperative outcomes among these groups. Microarray analysis revealed age-related upregulation of androgen and phosphatidylinositol 3-kinase pathways in the tumor tissue and downregulation of the fibrosis-related pathways in the noncancerous liver tissue. Conclusions Based on increased correlation with the absence of HBV and HCV infection and pre-existing comorbidity, the age-related carcinogenic pathways might play a critical role in elderly hepatocarcinogenesis.

本文言語English
ページ(範囲)450-456
ページ数7
ジャーナルAmerican Journal of Surgery
208
3
DOI
出版ステータスPublished - 2014 9

ASJC Scopus subject areas

  • Surgery

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