Affinity of a vancomycin polymer with bacterial surface models

Hirokazu Arimoto, Takehisa Oishi, Manabu Nishijima, Tomoya Kinumi

研究成果: Article

15 引用 (Scopus)

抜粋

The affinity between a vancomycin polymer (3) and cell wall intermediate mimics of vancomycin resistant bacteria (VRE) was determined by use of surface plasmon resonance (SPR). The increased affinity of 3 over monomeric vancomycin derivatives 1 and 2 suggests the importance of tighter binding to VRE surfaces in the enhanced antibacterial activities of 3.

元の言語English
ページ(範囲)3347-3350
ページ数4
ジャーナルTetrahedron Letters
42
発行部数19
DOI
出版物ステータスPublished - 2001 5 7
外部発表Yes

ASJC Scopus subject areas

  • Biochemistry
  • Organic Chemistry
  • Drug Discovery

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