抄録
In the previous study, we reported that the advanced glycation end products (AGEs) in the external space of neuronal perikarya (extraneuroperikaryal AGE deposits) were significantly abundant in the Alzheimer's brain. In this study, we investigated the spatial relationship of the extraneuroperikaryal AGE (carbocymethyllysine and pentosidine) deposits in astrocytes and microglial cells in the Alzheimer's disease brain using double immunolabelling for AGEs and astrocyte or microglial cell markers. Most of the extraneuroperikaryal AGE deposits were co-localized with glial fibrillary acidic protein-positive astrocytes. AGE deposit-bearing astrocytes also contained Gomori-positive granules. Furthermore, some of the extraneuroperikaryal AGE deposits were co-localized with microglial cells. These extraneuroperikaryal AGEs may activate astrocyte and microglia, and play a role in pathogenesis of Alzheimer's disease.
| 本文言語 | English |
|---|---|
| ページ（範囲） | 555-558 |
| ページ数 | 4 |
| ジャーナル | Acta neuropathologica |
| 巻 | 95 |
| 号 | 6 |
| DOI | |
| 出版ステータス | Published - 1998 |
| 外部発表 | はい |
ASJC Scopus subject areas
- 病理学および法医学
- 臨床神経学
- 細胞および分子神経科学