Advanced glycation end products co-localized with astrocytes and microglial cells in Alzheimer's disease brain

Akinori Takeda, Takeshi Yasuda, Toshio Miyata, Yoji Goto, Masakazu Wakai, Masaki Watanabe, Yoshinari Yasuda, Katsunori Horie, Toshiaki Inagaki, Manabu Doyu, Kenji Maeda, Gen Sobue

研究成果: Article査読

58 被引用数 (Scopus)

抄録

In the previous study, we reported that the advanced glycation end products (AGEs) in the external space of neuronal perikarya (extraneuroperikaryal AGE deposits) were significantly abundant in the Alzheimer's brain. In this study, we investigated the spatial relationship of the extraneuroperikaryal AGE (carbocymethyllysine and pentosidine) deposits in astrocytes and microglial cells in the Alzheimer's disease brain using double immunolabelling for AGEs and astrocyte or microglial cell markers. Most of the extraneuroperikaryal AGE deposits were co-localized with glial fibrillary acidic protein-positive astrocytes. AGE deposit-bearing astrocytes also contained Gomori-positive granules. Furthermore, some of the extraneuroperikaryal AGE deposits were co-localized with microglial cells. These extraneuroperikaryal AGEs may activate astrocyte and microglia, and play a role in pathogenesis of Alzheimer's disease.

本文言語English
ページ(範囲)555-558
ページ数4
ジャーナルActa neuropathologica
95
6
DOI
出版ステータスPublished - 1998
外部発表はい

ASJC Scopus subject areas

  • 病理学および法医学
  • 臨床神経学
  • 細胞および分子神経科学

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