Advanced glycation and lipoxidation end products: Reactive carbonyl compounds-related uraemic toxicity

Toshio Miyata, Akira Saito, Kiyoshi Kurokawa, Charles Van Ypersele De Strihou

研究成果: Article査読

38 被引用数 (Scopus)

抄録

Most studies on uraemic toxins have focused on disorders of enzymatic biochemistry. Recent studies to elucidate the pathogenesis of dialysis-related amyloidosis have provided new insights in progressive, irreversible protein modifications resulting from non-enzymatic biochemistry in uraemia. This paper focuses on two types of irreversible alterations of proteins: advanced glycation and lipoxidation. We investigate the causal role of various reactive carbonyl compounds (RCOs) accumulating in the serum, speculate on its clinical consequences, and discuss the therapeutic perspectives.

本文言語English
ページ(範囲)8-11
ページ数4
ジャーナルNephrology Dialysis Transplantation
16
SUPPL. 4
DOI
出版ステータスPublished - 2001
外部発表はい

ASJC Scopus subject areas

  • 腎臓病学
  • 移植

フィンガープリント

「Advanced glycation and lipoxidation end products: Reactive carbonyl compounds-related uraemic toxicity」の研究トピックを掘り下げます。これらがまとまってユニークなフィンガープリントを構成します。

引用スタイル