Adult t-cell leukemia derived from s100β positive double-negative (CD4- CD8-) t cells

Hitoshi Suzushima, Norio Asou, Toshio Hattori, Kiyoshi Takatsuki

研究成果: Article査読

16 被引用数 (Scopus)

抄録

Adult T-cell leukemia (ATL) is a mature T-cell malignancy which is caused by human T lymphotropic virus type-I (HTLV-I). Most of the ATL cells are CD3+, CD4+, CD8-, and T-cell receptor (TCR) aβ+ and also express activated antigens such as HLA-DR and inter-leukin-2 receptor (IL2R) α chain (CD25). Diminished surface expression of the TCRαbeta;CD3 complex is a specific feature of ATL cells. Since the gene transcript for each chain of this complex has been detected and surface expression of this complex is further decreased, accompanied by the induction of IL2Ra chain, after stimulation with anti-CD3 monoclonal antibody (mAb), the TCRαbeta;CD3 complex is considered to be down-modulated in vivo. We recently reported four ATL patients whose leukemic cells were CD4-, CD8- (double-negative; DN), TCRαbeta;+. These DN-ATL cells expressed S100αbeta; protein which was not detected in CD4+ ATL cells. Similar to CD4+ ATL cells, surface expression of the TCRαbeta;CD3 complex on DN-ATL cells was decreased in vivo despite the lack of CD4 or CD8 as core-ceptor. Therefore, the TCRαbeta;+ T-cell with or without CD4 is the sole target of HTLV-I induced leukemia and the down-modulation of the TCRαbeta;CD3 complex is considered to play a key role in the development of ATL.

本文言語English
ページ(範囲)257-262
ページ数6
ジャーナルLeukemia and Lymphoma
13
3-4
DOI
出版ステータスPublished - 1994
外部発表はい

ASJC Scopus subject areas

  • 血液学
  • 腫瘍学
  • 癌研究

フィンガープリント

「Adult t-cell leukemia derived from s100β positive double-negative (CD4<sup>-</sup> CD8<sup>-</sup>) t cells」の研究トピックを掘り下げます。これらがまとまってユニークなフィンガープリントを構成します。

引用スタイル