Adrenomedullin in human brain, adrenal glands and tumor tissues of pheochromocytoma, ganglioneuroblastoma and neuroblastoma

Fumitoshi Satoh, Kazuhiro Takahashi, Osamu Murakami, Kazuhito Totsune, Masahiko Sone, Makoto Ohneda, Keishi Abe, Yukio Miura, Yutaka Hayashi, Hironobu Sasano, Toraichi Mouri

研究成果: Article査読

152 被引用数 (Scopus)

抄録

Adrenomedullin is a potent vasodilator peptide that was isolated from human pheochromocytoma. But the presence of adrenomedullin in the brain has not been clarified. We studied the presence of adrenomedullin in the human brain obtained at autopsy from 6 subjects by radioimmunoassay, as well as in the human adrenal glands and tumor tissues of pheochromocytoma, ganglioneuroblastoma and neuroblastoma. Immunoreactive adrenomedullin was detected in every region of human brain examined (0.26 − 1.4 pmol/g wet weight) with the highest concentrations found in thalamus (1.40 ± 0.39 pmol/g wet weight, mean ± SEM) and hypothalamus (1.28 ± 0.48 pmol/g wet weight). Reverse phase high performance liquid chromatography showed that the immunoreactive adrenomedullin in the human brain was eluted in the position of synthetic human adrenomedullin 1–52. High concentrations of immunoreactive adrenomedullin were found in human adrenal glands (12.6 ± 1.0 pmol/g wet weight, n = 7), pheochromocytoma (4.5 ± 1.5 pmol/g wet weight, n = 11), ganglioneuroblastoma (2.0 ± 1.3 pmol/g wet weight, n = 4) and neuroblastoma (0.55 ± 0.21 pmol/g wet weight, n = 3). The present study has shown that adrenomedullin is present in the human brain in high concentrations, suggesting that adrenomedullin acts as a neurotransmitter, neuromodulator or neurohormone in man.

本文言語English
ページ(範囲)1750-1752
ページ数3
ジャーナルJournal of Clinical Endocrinology and Metabolism
80
5
DOI
出版ステータスPublished - 1995 1 1

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Biochemistry
  • Endocrinology
  • Clinical Biochemistry
  • Biochemistry, medical

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